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Platinum Toxicity

Platinum (Pt)

Platinum is a nonessential element that can be found at elevated concentrations in urine with excessive exposure. Industrial workers exposed to Platinum showed higher concentrations in the blood and urine (> 2 μg Platinum/24 hours) in comparison to non-exposed workers. Platinum is poorly absorbed in the gut but may be absorbed via inhalation. Since it is a relatively rare element, most Platinum exposures are of occupational origin. In recent years, there may have been a slight increase in environmental Platinum due to the use of Platinum as a catalyst in automobile exhaust converters. Platinum is a byproduct of copper refining and used as an alloy in dental and orthopedic materials. Symptoms of excess exposure to Platinum include: dermatitis, irritation of mucus membranes, shortness of breath and wheezing (for inhaled Platinum dusts or salts), development of chronic allergic reactions ("platinosis"), nephritis, and immune system suppression (from Platinum diamine salts). Platinum containing drugs, such as cisplatin and carboplatin, are used as chemotherapeutic agents. Such drugs are extremely toxic and cause nephrotoxicity with associated magnesium wasting and hypomagnesaemia (low magnesium), myelosuppression, inner ear toxicity, and neurotoxicity.  Urinary Platinum can be significantly elevated for patients that have received the Platinum containing chemotherapeutic agents.

Platinum can be tested in the hair, urine, feces or blood. If you suspect that you have an elevated Platinum level, Hair is a good indicator of long term, chronic, exposure to platinum, and can be easily done at home with a Hair Analysis kit, which also measures other toxic metals, and hair nutritional elements.

Here at Chelation Medical Center we can do an IV chelation provoked challenge to determine total body load of Platinum as well as other heavy metals followed by a urine metals test collection.  Just give us a call or send an email.

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