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Analysis of Gadolinium in feces provides indirect information about the potential for Gadolinium metal burden. For many toxic metals, fecal (biliary) excretion is the primary natural route of elimination from the body. Fecal elemental analysis also provides a direct indication of dietary exposure to toxic metals. Specimen collection is convenient for the patient and only requires a single-step procedure.
Gadolinium (Gd) is a toxic element used in the medical field with magnetic resonance imaging (MRI). After it is injected into the body, Gd is primarily excreted through the kidneys. Excessive gadolinium levels can be a factor in kidney and renal filtration disorders. Analysis of Gd in feces provides an evaluation of exposure, potential for accumulation in the body, and possibly endogenous detoxification of this potentially toxic metal. The primary process by which the body eliminates the insidious sulfhydryl reactive metals is through the formation of metal-glutathione complexes, of which greater than 90% are excreted into the bile.
The most commonly observed source of Gd is the administration of a Gd injection dye while receiving an MRI. Generally the body processes and eliminates the concentration of a Gd within four days, however, significant retention can occur in patients with pre-existing kidney disease. Administration of pharmaceutical metal binding agents results in excretion of toxic metals primarily through the kidneys into the urine. In contrast, support of natural detoxification processes enhances the rate of excretion of toxic metals into the feces. Elemental analysis of fecal specimens can provide a valuable tool to monitor the efficacy of natural detoxification of metals in infants or patients who are on very limited and defined diets that do not contain contaminated solid foods. A preliminary study performed at Doctor’s Data indicates that biliary/fecal excretion may be enhanced following high dose intravenous administration of ascorbic acid. Other orthomolecular or nutraceutical protocols may also enhance the fecal excretion of metals and hence potentially decrease burden on the kidneys. Further research to identify and validate such therapies is warranted.
The fecal metals test was not developed to replace the pre and post urinary toxic metals provocation test, but rather provides an alternative for infants, children or adults for whom urine collection is problematic, or for individuals who do not tolerate the available pharmaceutical metal detoxification agents. Toxic elements are measured by ICP-MS and expressed on a dry weight basis to eliminate variability related to water content of the specimen.More Doctors Data Lab Tests