Who knew that Celiac Disease, Inflammatory Bowel Disease, Multiple Sclerosis, Cancer, Type 1 Diabetes, Asthma and Schizophrenia can all be related to a leaky gut! Zonulin is a protein bio marker that causes the tightly bound protein in the intestinal lining to open. That allows for the passage of toxins, bacterial lipopolysaccharides, inflammatory cytokines and antibodies to enter through the gut into the circulation via intestinal permeability or leaky gut. Now Zonulin is triggered by the endothelial cells exposure to gliadin and pathogenic bacteria. Gliadin, a component of gluten, is found in wheat and other grains of the grass family; we all have pathogenic bacteria in our gut, but if we have enough good bacteria, the bad guys loose out! Thus the need for probiotics. Replacing the gut flora with probiotics daily will help prevent leaky gut and all the problems associated with it. It has also been found that zinc supports healthy immune function and enhances the barrier function in the gut.