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Mercury (Hg)
Presentation of symptoms associated with excessive mercury can depend on many factors: the chemical form of absorbed Hg and its transport in body tissues, presence of other synergistic toxics (lead and cadmium have such effects), presence of disease that depletes or inactivates lymphocytes or is immunosuppressive, organ levels of xenobiotic chemicals and sulfhydryl-bearing metabolites (e.g. glutathione), and the concentration of protective nutrients, (e.g. zinc, selenium, vitamin E). Early signs of mercury contamination include: decreased senses of touch, hearing, vision and taste, metallic taste in mouth, fatigue or lack of physical endurance, and increased salivation. Symptoms may progress with moderate or chronic exposure to include: anorexia, numbness and paresthesias, headaches, hypertension, irritability and excitability, and immune suppression, possibly immune system dysfunction. Advanced disease processes from mercury toxicity include: tremors and incoordination, anemia,psychoses, manic behaviors, possibly autoimmune disorders, kidney dysfunction or failure, neurological diseases such as autism, alzheimers, parkinsons, MS. Mercury is commonly used in: dental amalgams, vaccines, explosive detonators; in pure liquid form for thermometers, barometers, and laboratory equipment; batteries and electrodes (”calomel”); and in fungicides and pesticides. The fungicide/pesticide use of mercury has declined due to environmental concerns, but mercury residues persist from past use. Methylmercury, the common, poisonous form, occurs by methylation in aquatic biota or sediments (both freshwater and ocean sediments). Methylmercury accumulates in aquatic animals and fish and is concentrated up the food chain reaching high concentrations in large fish and predatory birds. Except for fish, the human intake of dietary mercury is negligible unless the food is contaminated with one of the previously listed forms/sources. A daily diet of fish can cause 1 to 10 micrograms of mercury/day to be ingested, with about three-quarters of this (typically) as methylmercury. Depending upon body burden and upon type, duration and dosage of detoxifying agents, elevated urine mercury may occur after administration of: DMPS, DMSA, D-penicillamine, or EDTA. Elemental analysis of hair can be a secondary corroborating test for mercury burden. Blood and especially blood cell analyses are only useful for diagnosing very recent or ongoing organic (methyl) mercury exposure.